Projects and Publications

Projects Obtained

Our Publications

Our lab publications from VIT, Vellore

22. J. L., B.J., Dhanasingh, I. An update on thermostable keratinases for protein engineering against feather pollutants. Appl Microbiol Biotechnol 109, 75 (2025). https://doi.org/10.1007/s00253-025-13459-5

21. Singh, S., Kumar. S, Dhanasingh I*. In-silico identification of flavonoids based inhibitors against sortase-A from Enterococcus Faecalis. Journal of Microbiology, biotechnology and food sciences (2024). https://doi.org/10.55251/jmbfs.11256

20. Singh, S., Kumar. S, Dhanasingh I*. Overexpression, Purification and Biochemical studies of Sortase A from E. faecalis and its inhibition studies with Aloenin. Acta Tropica (2024). https://doi.org/10.1016/j.actatropica.2024.107419

19. Mahalingam, G., Arjunan, P., Periyasami, Y. Y. Dhyani, A. Kumar, D. Nivedita, R.Vignesh, C. Abisha Crystal, Kt, Ramya Devi, I.Dhanasingh, T.Saravanabhavan, M. Mohankumar, M. Mahesh, A. Srivastava, M. Srujan. Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor. Sci Rep 13, 8743 (2023). https://doi.org/10.1038/s41598-023-35070-2

PI's publications prior to VIT

18. J.Y. Park, D.D.Lee, J.J.Lee, J.Gim, T.I.Gunasekaran, K.Y.Choi, S.Kang, A.R.Do, J.Jo, J.Park, D.Li, S.Lee, H.Kim, I.Dhanasingh, S.Ghosh, S.Keum, J.H.Choi, G.J.Song, L.Sael, S.Rhee, S.Lovestone, E.Kim, S.H.Moon, B.C.Kim, S.Kim, A.J.Saykin, K.Nho, S.H.Lee, L.A.Farrer, G.R.Jun, S.Won, K.H.Lee. A missense variant in SHARPIN mediates Alzheimer’s disease-specific brain damages. Translational Psychiatry 11, 590 (2021) Nov. (I.F: 6.222)

17. H.S. Jin*, I. I.Dhanasingh*, J.Y.Sung, J.W.La, E.M.Lee, Y.Kang, D.Y.Lee, S.H.Lee, D.W.Lee. The Sulfur Formation System Mediating Extracellular Cysteine-Cystine Recycling in in Fervidobacterium islandicum AW-1 Is Associated with Keratin Degradation. Microbial Biotechnology (2021) May; 14(3): 938–952. (I.F:5.813) (Co-First Author)  

16. I. Dhanasingh*, J.Y.J.Y.Sung*, J.W.La, E.Kang, D.W.Lee, S.H.Lee. Structure of oxidized pyrrolidone carboxypeptidase from Fervidobacterium islandicum AW-1 reveals unique structural features for thermostability and keratinolysis. Biochem Biophys Res Commun, (2021) Feb 12;540:101-107 (I.F:3.575) (Co-First Author)  

15. I. Dhanasingh, E. Choi*, J.Lee, S.H.Lee, J.Hwang. Functional and Structural Characterization of Deinococcus radiodurans R1 MazEF toxin-antitoxin System, Dr0416-Dr0417. Journal of Microbiology, (2021) Feb;59(2):186-201 (I.F:3.422) (Co-First Author).  

14. J.W.La*, I.Dhanasingh*,  H.Jang, S.H.Lee, D.W.Lee. Functional Characterization of Primordial Protein Repair Enzyme M38 Metallo-Peptidase from Fervidobacterium islandicum AW-1. Frontiers in Molecular Biosciences, (2020) doi: 10.3389/fmolb.2020.600634 (I.F: 5.246) (Co-First Author)  

13.   T.P. Cao, H.Yi, I. Dhanasingh, S.Ghosh, J.M.Choi, K.H.Lee, S.Ryu, H.S.Kim, S.H.Lee. Non-Catalytic-

Region mutations conferring Transition of Class A β-lactamases into ESBLs, Frontiers in Molecular Biosciences, (2020) Front. Mol. Biosci. 7:598998. (I.F: 5.246)  

12. S. Ghosh*, I. I.Dhanasingh*, J.Ryu, S.W.Kim, S.H.Lee. Crystal Structure of Cytochrome cL from the Aquatic methylotrophic bacterium Methylophaga aminisulfidivorans MPT. Journal of Microbiology and Biotechnology (2020) 30 (8): 1261-1271 (I.F: 2.351) (Co-First Author)  

11. I. Dhanasingh S.H. Lee. Crystallization and preliminary X-ray diffraction analysis of Thioredoxin from the feather-degrading thermophile Fervidobacterium islandicum AW-1. Bio Design, (2019) June, vol 2; 47-51 doi:10.34184/kssb.2019.7.2.1  

10. I. Dhanasingh E. Choi, J.Hwang and S.H. Lee. Crystallization and preliminary X-ray diffraction analysis of a toxin-antitoxin MazEF complex from the extremophile Deinococcus radiodurans. Bio Design, (2018) 2327(First Author)  

9.   R. Kanteti, T. Mirzapoiazova, J.J. Riehm, I. Dhanasingh, B. Mambetsariev, J. Wang, P. Kulkarni, G. Kaushik, P. Seshacharyulu, M.P. Ponnusamy, H.L. Kindler, M.W. Nasser, S.K. Batra, R. Salgia, Focal  Adhesion Kinase a Potential Therapeutic Target for Pancreatic Cancer and Malignant Pleural  

Mesothelioma, Cancer Biol Ther, (2018) 0. (I.F: 4.742; Citation count: 36)  

8. R. Kanteti, J.J. Riehm, I. Dhanasingh, F.E. Lennon, T. Mirzapoiazova, B. Mambetsariev, H.L. Kindler, R. Salgia, PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma, Sci Rep, 6 (2016) 32992. (I.F: 4.379; Citation count: 17)  

7. R. Kanteti, I. Dhanasingh, E. El-Hashani, J.J. Riehm, T. Stricker, S. Nagy, A. Zaborin, O. Zaborina, D. Biron, J.C. Alverdy, H.K. Im, S. Siddiqui, P.A. Padilla, R. Salgia, C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype, Cancer Biol Ther, 17 (2016) 91-103. (I.F: 4.742; Citation count:4)  

6.   Y.J. Lee*, I. Dhanasingh*,  J.S. Ahn, H.S. Jin, J.M. Choi, S.H. Lee, D.W. Lee, Biochemical and structural characterization of a keratin-degrading M32 carboxypeptidase from Fervidobacterium islandicum AW-1, Biochem Biophys Res Commun, 468 (2015) 927-933 (I.F: 3.575; Citation count:15) (Co-First Author)  

5. I. Dhanasingh J.M. Choi and S.H. Lee. Karyopherins and Nuclear actin transport (mini review). Bio Design, (2015) 88-97(Citation count:1) (First Author)  

4. R. Kanteti, I. Dhanasingh, I. Kawada, F.E. Lennon, Q. Arif, R. Bueno, R. Hasina, A.N. Husain, W. Vigneswaran, T. Seiwert, H.L. Kindler, R. Salgia, MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma, PLoS One, 9 (2014) e105919. (I.F: 3.24; Citation count:47)  

3. C.E. Rolle, R. Kanteti, M. Surati, S. Nandi, I. Dhanasingh, S. Yala, M. Tretiakova, Q. Arif, T. Hembrough, T.M. Brand, D.L. Wheeler, A.N. Husain, E.E. Vokes, A. Bharti, R. Salgia, Combined MET inhibition and topoisomerase I inhibition block cell growth of small cell lung cancer, Mol Cancer Ther, 13 (2014) 576584. (I.F: 6.261; Citation count:17)  

2. R. Kanteti, E. El-Hashani, I. Dhanasingh, M. Tretiakova, A.N. Husain, S. Sharma, J. Sharma, E.E. Vokes, R. Salgia, Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer, BMC Cancer, 14 (2014) 185. (I.F: 4.4; Citation count:12)  

1. H.J. Chang, I. Dhanasingh, X. Gou, A.M. Rice, M.S. Dushay, Loss of Hemolectin reduces the survival of  Drosophila larvae after wounding, Dev Comp Immunol, 36 (2012) 274-278. (I.F: 3.636; Citation count:16)